L15I (p.Leu15Ile) variant of TLR7 (Toll-like receptor 7)
L15I (p.Leu15Ile) in TLR7 (Toll-like receptor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
L15I (p.Leu15Ile) variant details
- p.Leu15Ile
- Ensembl rs952821919
- Missense
- Variant Prioritization Score for Impact Estimate 0.251
- REVEL 0.02
- MetaLR 0.08
- MetaSVM -1.05
- CADD 7.92
- PolyPhen-2 0.02
- SIFT 0.17
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available