K9N (p.Lys9Asn) variant of TLR7 (Toll-like receptor 7)
K9N (p.Lys9Asn) in TLR7 (Toll-like receptor 7) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
K9N (p.Lys9Asn) variant details
- p.Lys9Asn
- rs1191062173
- TOPMed rs1191062173
- gnomAD rs1191062173
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.136
- REVEL 0.06
- MetaLR 0.07
- MetaSVM -1.01
- CADD 10.30
- PolyPhen-2 0.00
- SIFT 0.27
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 9.7e-05)
- Structural context available