I19T (p.Ile19Thr) variant of TLR7 (Toll-like receptor 7)
I19T (p.Ile19Thr) in TLR7 (Toll-like receptor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data, published literature, and structural context.
I19T (p.Ile19Thr) variant details
- p.Ile19Thr
- gnomAD X-12885564-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.23
- REVEL 0.14
- MetaLR 0.12
- MetaSVM -0.98
- CADD 13.40
- PolyPhen-2 0.00
- SIFT 0.37
- Most common in the Non-Finnish European population (allele frequency 6e-06)
- Structural context available
- Literature evidence available