H86L (p.His86Leu) variant of TLR7 (Toll-like receptor 7)
H86L (p.His86Leu) in TLR7 (Toll-like receptor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
H86L (p.His86Leu) variant details
- p.His86Leu
- ExAC rs200654867
- gnomAD rs200654867
- Missense
- Variant Prioritization Score for Impact Estimate 0.0898
- REVEL 0.03
- MetaLR 0.01
- MetaSVM -0.91
- CADD 7.91
- PolyPhen-2 0.00
- SIFT 0.31
- Most common in the South Asian population (allele frequency 0.00015)
- Structural context available