H46R (p.His46Arg) variant of TLR7 (Toll-like receptor 7)
H46R (p.His46Arg) in TLR7 (Toll-like receptor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
H46R (p.His46Arg) variant details
- p.His46Arg
- ExAC rs766652668
- gnomAD rs766652668
- Missense
- Variant Prioritization Score for Impact Estimate 0.197
- REVEL 0.13
- MetaLR 0.01
- MetaSVM -0.91
- CADD 9.00
- PolyPhen-2 0.03
- SIFT 0.27
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available