G62C (p.Gly62Cys) variant of TLR7 (Toll-like receptor 7)
G62C (p.Gly62Cys) in TLR7 (Toll-like receptor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
G62C (p.Gly62Cys) variant details
- p.Gly62Cys
- TOPMed rs958741253
- Missense
- Variant Prioritization Score for Impact Estimate 0.441
- REVEL 0.34
- AlphaMissense 0.31
- MetaLR 0.36
- MetaSVM -0.10
- CADD 23.10
- PolyPhen-2 0.89
- Most common in the Non-Finnish European population (allele frequency 1.9e-05)
- Structural context available