G125V (p.Gly125Val) variant of TLR7 (Toll-like receptor 7)
G125V (p.Gly125Val) in TLR7 (Toll-like receptor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
G125V (p.Gly125Val) variant details
- p.Gly125Val
- gnomAD rs1461048823
- Missense
- Variant Prioritization Score for Impact Estimate 0.108
- REVEL 0.07
- MetaLR 0.01
- MetaSVM -0.94
- CADD 7.79
- PolyPhen-2 0.00
- SIFT 0.06
- Most common in the Latino/Admixed American population (allele frequency 8.5e-05)
- Structural context available