D95N (p.Asp95Asn) variant of TLR7 (Toll-like receptor 7)
D95N (p.Asp95Asn) in TLR7 (Toll-like receptor 7) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
D95N (p.Asp95Asn) variant details
- p.Asp95Asn
- rs200138463
- NCI-TCGA Cosmic COSV1010
- Ensembl rs200138463
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.373
- REVEL 0.28
- MetaLR 0.01
- MetaSVM -0.94
- CADD 22.50
- PolyPhen-2 0.43
- SIFT 0.30
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available