V33L (p.Val33Leu) variant of TLR4 (Toll-like receptor 4)
V33L (p.Val33Leu) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
V33L (p.Val33Leu) variant details
- p.Val33Leu
- ExAC rs200405562
- TOPMed rs200405562
- gnomAD rs200405562
- Missense
- Variant Prioritization Score for Impact Estimate 0.149
- REVEL 0.04
- CADD 17.00
- PolyPhen-2 0.00
- SIFT 0.10
- Most common in the African/African-American population (allele frequency 9.7e-05)
- Structural context available