S5L (p.Ser5Leu) variant of TLR4 (Toll-like receptor 4)
S5L (p.Ser5Leu) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.04 / 1. The record also includes population frequency data and structural context.
S5L (p.Ser5Leu) variant details
- p.Ser5Leu
- cosmic curated COSV10467
- TOPMed rs1588091037
- Missense
- Variant Prioritization Score for Impact Estimate 0.0378
- REVEL 0.01
- CADD 1.06
- PolyPhen-2 0.00
- SIFT 0.68
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available