S55L (p.Ser55Leu) variant of TLR4 (Toll-like receptor 4)
S55L (p.Ser55Leu) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
S55L (p.Ser55Leu) variant details
- p.Ser55Leu
- cosmic curated COSV62922
- gnomAD rs1829178045
- Missense
- Variant Prioritization Score for Impact Estimate 0.498
- REVEL 0.29
- CADD 25.00
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available