R6C (p.Arg6Cys) variant of TLR4 (Toll-like receptor 4)
R6C (p.Arg6Cys) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.06 / 1. The record also includes population frequency data and structural context.
R6C (p.Arg6Cys) variant details
- p.Arg6Cys
- ExAC rs763056825
- TOPMed rs763056825
- gnomAD rs763056825
- Missense
- Variant Prioritization Score for Impact Estimate 0.064
- REVEL 0.02
- CADD 8.98
- PolyPhen-2 0.00
- SIFT 0.12
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available