Q39L (p.Gln39Leu) variant of TLR4 (Toll-like receptor 4)
Q39L (p.Gln39Leu) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
Q39L (p.Gln39Leu) variant details
- p.Gln39Leu
- gnomAD 9-117708585-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.322
- REVEL 0.20
- CADD 21.90
- PolyPhen-2 0.13
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available