P65S (p.Pro65Ser) variant of TLR4 (Toll-like receptor 4)
P65S (p.Pro65Ser) in TLR4 (Toll-like receptor 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
P65S (p.Pro65Ser) variant details
- p.Pro65Ser
- rs772783306
- NCI-TCGA Cosmic COSV1007
- cosmic curated COSV10079
- NCI-TCGA Cosmic COSV6292
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.197
- REVEL 0.17
- CADD 9.83
- PolyPhen-2 0.20
- SIFT 0.41
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available