P65L (p.Pro65Leu) variant of TLR4 (Toll-like receptor 4)
P65L (p.Pro65Leu) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
P65L (p.Pro65Leu) variant details
- p.Pro65Leu
- cosmic curated COSV62924
- gnomAD rs868087145
- Missense
- Variant Prioritization Score for Impact Estimate 0.163
- REVEL 0.05
- CADD 10.90
- PolyPhen-2 0.11
- SIFT 0.68
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available