P65A (p.Pro65Ala) variant of TLR4 (Toll-like receptor 4)
P65A (p.Pro65Ala) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
P65A (p.Pro65Ala) variant details
- p.Pro65Ala
- cosmic curated COSV10591
- ExAC rs772783306
- TOPMed rs772783306
- gnomAD rs772783306
- Missense
- Variant Prioritization Score for Impact Estimate 0.165
- REVEL 0.13
- CADD 7.67
- PolyPhen-2 0.28
- SIFT 0.49
- Most common in the HGDP:NORTHERNHAN population (allele frequency 0.05)
- Structural context available