P34S (p.Pro34Ser) variant of TLR4 (Toll-like receptor 4)
P34S (p.Pro34Ser) in TLR4 (Toll-like receptor 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
P34S (p.Pro34Ser) variant details
- p.Pro34Ser
- NCI-TCGA Cosmic COSV6292
- cosmic curated COSV62923
- Ensembl rs1829176200
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.259
- REVEL 0.13
- CADD 22.30
- PolyPhen-2 0.03
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 0.00015)
- Structural context available