P28T (p.Pro28Thr) variant of TLR4 (Toll-like receptor 4)
P28T (p.Pro28Thr) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data, published literature, and structural context.
P28T (p.Pro28Thr) variant details
- p.Pro28Thr
- gnomAD 9-117704554-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.417
- REVEL 0.15
- CADD 25.30
- PolyPhen-2 0.76
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available