P28S (p.Pro28Ser) variant of TLR4 (Toll-like receptor 4)
P28S (p.Pro28Ser) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
P28S (p.Pro28Ser) variant details
- p.Pro28Ser
- gnomAD 9-117704554-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.324
- REVEL 0.02
- CADD 23.80
- PolyPhen-2 0.11
- SIFT 0.13
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available