P23R (p.Pro23Arg) variant of TLR4 (Toll-like receptor 4)
P23R (p.Pro23Arg) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data, published literature, and structural context.
P23R (p.Pro23Arg) variant details
- p.Pro23Arg
- gnomAD 9-117704540-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.372
- REVEL 0.16
- CADD 23.50
- PolyPhen-2 0.57
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available
- Literature evidence available