N35S (p.Asn35Ser) variant of TLR4 (Toll-like receptor 4)
N35S (p.Asn35Ser) in TLR4 (Toll-like receptor 4) is a missense change. Clinical records from ClinVar and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
N35S (p.Asn35Ser) variant details
- p.Asn35Ser
- gnomAD rs1829176377
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.257
- REVEL 0.09
- CADD 18.40
- ClinVar: Likely benign (not specified)
- UniProt: Likely benign
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available