L59V (p.Leu59Val) variant of TLR4 (Toll-like receptor 4)
L59V (p.Leu59Val) in TLR4 (Toll-like receptor 4) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes structural context.
L59V (p.Leu59Val) variant details
- p.Leu59Val
- rs892362464
- ClinGen CA374653207
- ClinVar RCV004237422
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.543
- AlphaMissense 0.25
- MetaLR 0.66
- MetaSVM -0.17
- PolyPhen-2 1.00
- SIFT 0.00
- MutPred 0.64
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available