L59M (p.Leu59Met) variant of TLR4 (Toll-like receptor 4)
L59M (p.Leu59Met) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
L59M (p.Leu59Met) variant details
- p.Leu59Met
- TOPMed rs892362464
- gnomAD rs892362464
- Missense
- Variant Prioritization Score for Impact Estimate 0.396
- REVEL 0.29
- AlphaMissense 0.25
- MetaLR 0.66
- MetaSVM -0.17
- CADD 19.00
- PolyPhen-2 1.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available