K57R (p.Lys57Arg) variant of TLR4 (Toll-like receptor 4)
K57R (p.Lys57Arg) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
K57R (p.Lys57Arg) variant details
- p.Lys57Arg
- gnomAD rs981483029
- Missense
- Variant Prioritization Score for Impact Estimate 0.228
- REVEL 0.07
- CADD 23.00
- PolyPhen-2 0.21
- SIFT 0.04
- Most common in the HGDP:PAPUANSEPIK population (allele frequency 0.5)
- Structural context available