G70S (p.Gly70Ser) variant of TLR4 (Toll-like receptor 4)
G70S (p.Gly70Ser) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
G70S (p.Gly70Ser) variant details
- p.Gly70Ser
- TOPMed rs1217519172
- gnomAD rs1217519172
- Missense
- Variant Prioritization Score for Impact Estimate 0.265
- REVEL 0.04
- CADD 10.90
- PolyPhen-2 0.05
- SIFT 0.21
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available