E42Q (p.Glu42Gln) variant of TLR4 (Toll-like receptor 4)
E42Q (p.Glu42Gln) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
E42Q (p.Glu42Gln) variant details
- p.Glu42Gln
- ExAC rs746061968
- TOPMed rs746061968
- gnomAD rs746061968
- Missense
- Variant Prioritization Score for Impact Estimate 0.352
- REVEL 0.12
- CADD 23.80
- PolyPhen-2 0.42
- SIFT 0.15
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available