E27Q (p.Glu27Gln) variant of TLR4 (Toll-like receptor 4)
E27Q (p.Glu27Gln) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
E27Q (p.Glu27Gln) variant details
- p.Glu27Gln
- TOPMed rs200144068
- gnomAD rs200144068
- Missense
- Variant Prioritization Score for Impact Estimate 0.174
- REVEL 0.03
- CADD 22.50
- PolyPhen-2 0.02
- SIFT 0.37
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available