C40Y (p.Cys40Tyr) variant of TLR4 (Toll-like receptor 4)
C40Y (p.Cys40Tyr) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data and structural context.
C40Y (p.Cys40Tyr) variant details
- p.Cys40Tyr
- ExAC rs779025130
- TOPMed rs779025130
- gnomAD rs779025130
- Missense
- Variant Prioritization Score for Impact Estimate 0.691
- REVEL 0.62
- CADD 26.60
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Finnish in Finland (FIN) population (allele frequency 5.6e-05)
- Structural context available