C20W (p.Cys20Trp) variant of TLR4 (Toll-like receptor 4)
C20W (p.Cys20Trp) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, published literature, and structural context.
C20W (p.Cys20Trp) variant details
- p.Cys20Trp
- gnomAD 9-117704532-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.33
- REVEL 0.31
- CADD 26.80
- PolyPhen-2 0.82
- SIFT 0.07
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- Literature evidence available