C20S (p.Cys20Ser) variant of TLR4 (Toll-like receptor 4)
C20S (p.Cys20Ser) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
C20S (p.Cys20Ser) variant details
- p.Cys20Ser
- ExAC rs763655001
- gnomAD rs763655001
- Missense
- Variant Prioritization Score for Impact Estimate 0.253
- REVEL 0.21
- CADD 23.80
- PolyPhen-2 0.02
- SIFT 0.25
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available