A8G (p.Ala8Gly) variant of TLR4 (Toll-like receptor 4)
A8G (p.Ala8Gly) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
A8G (p.Ala8Gly) variant details
- p.Ala8Gly
- ExAC rs774003809
- TOPMed rs774003809
- gnomAD rs774003809
- Missense
- Variant Prioritization Score for Impact Estimate 0.271
- REVEL 0.06
- CADD 24.60
- PolyPhen-2 0.57
- SIFT 0.08
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available