A4V (p.Ala4Val) variant of TLR4 (Toll-like receptor 4)
A4V (p.Ala4Val) in TLR4 (Toll-like receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.04 / 1. The record also includes population frequency data and structural context.
A4V (p.Ala4Val) variant details
- p.Ala4Val
- TOPMed rs540134484
- gnomAD rs540134484
- Missense
- Variant Prioritization Score for Impact Estimate 0.0386
- REVEL 0.02
- CADD 0.15
- PolyPhen-2 0.00
- SIFT 0.58
- Most common in the HGDP:SAN population (allele frequency 0.083)
- Structural context available