Y74N (p.Tyr74Asn) variant of TLR3 (Toll-like receptor 3)
Y74N (p.Tyr74Asn) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data, published literature, and structural context.
Y74N (p.Tyr74Asn) variant details
- p.Tyr74Asn
- gnomAD 4-186076839-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.663
- REVEL 0.71
- MetaLR 0.59
- MetaSVM 0.26
- CADD 24.50
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available