Y74H (p.Tyr74His) variant of TLR3 (Toll-like receptor 3)
Y74H (p.Tyr74His) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data, published literature, and structural context.
Y74H (p.Tyr74His) variant details
- p.Tyr74His
- gnomAD 4-186076839-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.647
- REVEL 0.68
- MetaLR 0.60
- MetaSVM 0.29
- CADD 24.50
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available