W11S (p.Trp11Ser) variant of TLR3 (Toll-like receptor 3)
W11S (p.Trp11Ser) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
W11S (p.Trp11Ser) variant details
- p.Trp11Ser
- ExAC rs750233576
- TOPMed rs750233576
- gnomAD rs750233576
- Missense
- Variant Prioritization Score for Impact Estimate 0.179
- REVEL 0.12
- MetaLR 0.04
- MetaSVM -1.05
- CADD 9.89
- PolyPhen-2 0.00
- SIFT 0.17
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available