W11C (p.Trp11Cys) variant of TLR3 (Toll-like receptor 3)
W11C (p.Trp11Cys) in TLR3 (Toll-like receptor 3) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Herpes simplex encephalitis, susceptibility to, 1; not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
W11C (p.Trp11Cys) variant details
- p.Trp11Cys
- rs755127843
- ClinGen CA3161143
- ClinVar RCV003067728
- ClinVar RCV004071670
- Uncertain significance
- Herpes simplex encephalitis, susceptibility to, 1; not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.112
- REVEL 0.06
- MetaLR 0.03
- MetaSVM -1.04
- CADD 11.80
- PolyPhen-2 0.05
- SIFT 0.06
- ClinVar: Uncertain significance (Herpes simplex encephalitis, susceptibility to, 1; not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available