V45L (p.Val45Leu) variant of TLR3 (Toll-like receptor 3)
V45L (p.Val45Leu) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
V45L (p.Val45Leu) variant details
- p.Val45Leu
- Ensembl rs1561370160
- Missense
- Variant Prioritization Score for Impact Estimate 0.202
- REVEL 0.17
- MetaLR 0.13
- MetaSVM -1.02
- CADD 6.78
- PolyPhen-2 0.03
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available