T72K (p.Thr72Lys) variant of TLR3 (Toll-like receptor 3)
T72K (p.Thr72Lys) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data, published literature, and structural context.
T72K (p.Thr72Lys) variant details
- p.Thr72Lys
- gnomAD 4-186076834-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.435
- REVEL 0.30
- MetaLR 0.23
- MetaSVM -0.79
- CADD 16.30
- PolyPhen-2 0.20
- SIFT 0.19
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available