T54R (p.Thr54Arg) variant of TLR3 (Toll-like receptor 3)
T54R (p.Thr54Arg) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
T54R (p.Thr54Arg) variant details
- p.Thr54Arg
- ExAC rs751015522
- TOPMed rs751015522
- gnomAD rs751015522
- Missense
- Variant Prioritization Score for Impact Estimate 0.363
- REVEL 0.30
- MetaLR 0.19
- MetaSVM -0.80
- CADD 23.30
- PolyPhen-2 0.97
- SIFT 0.05
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available