S75R (p.Ser75Arg) variant of TLR3 (Toll-like receptor 3)
S75R (p.Ser75Arg) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data, published literature, and structural context.
S75R (p.Ser75Arg) variant details
- p.Ser75Arg
- gnomAD 4-186076844-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.0844
- REVEL 0.05
- MetaLR 0.08
- MetaSVM -1.06
- CADD 0.44
- PolyPhen-2 0.01
- SIFT 0.37
- Most common in the Ashkenazi Jewish population (allele frequency 3.8e-05)
- Structural context available
- Literature evidence available