S38G (p.Ser38Gly) variant of TLR3 (Toll-like receptor 3)
S38G (p.Ser38Gly) in TLR3 (Toll-like receptor 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
S38G (p.Ser38Gly) variant details
- p.Ser38Gly
- rs1418733023
- NCI-TCGA Cosmic COSV9971
- gnomAD rs1418733023
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.458
- REVEL 0.38
- MetaLR 0.29
- MetaSVM -0.45
- CADD 25.10
- PolyPhen-2 0.97
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available