R65G (p.Arg65Gly) variant of TLR3 (Toll-like receptor 3)
R65G (p.Arg65Gly) in TLR3 (Toll-like receptor 3) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
R65G (p.Arg65Gly) variant details
- p.Arg65Gly
- TOPMed rs1426754278
- gnomAD rs1426754278
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.205
- REVEL 0.16
- MetaLR 0.15
- MetaSVM -1.02
- CADD 14.00
- PolyPhen-2 0.00
- SIFT 0.64
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available