R2T (p.Arg2Thr) variant of TLR3 (Toll-like receptor 3)
R2T (p.Arg2Thr) in TLR3 (Toll-like receptor 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
R2T (p.Arg2Thr) variant details
- p.Arg2Thr
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.127
- REVEL 0.04
- MetaLR 0.05
- MetaSVM -1.04
- CADD 8.72
- PolyPhen-2 0.01
- SIFT 0.16
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available