P50S (p.Pro50Ser) variant of TLR3 (Toll-like receptor 3)
P50S (p.Pro50Ser) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
P50S (p.Pro50Ser) variant details
- p.Pro50Ser
- gnomAD rs1297171122
- Missense
- Variant Prioritization Score for Impact Estimate 0.611
- REVEL 0.62
- MetaLR 0.52
- MetaSVM 0.09
- CADD 23.30
- PolyPhen-2 0.95
- SIFT 0.02
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available