P50H (p.Pro50His) variant of TLR3 (Toll-like receptor 3)
P50H (p.Pro50His) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.74 / 1. The record also includes population frequency data, published literature, and structural context.
P50H (p.Pro50His) variant details
- p.Pro50His
- gnomAD 4-186076768-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.738
- REVEL 0.71
- MetaLR 0.68
- MetaSVM 0.67
- CADD 23.50
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available