N70S (p.Asn70Ser) variant of TLR3 (Toll-like receptor 3)
N70S (p.Asn70Ser) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
N70S (p.Asn70Ser) variant details
- p.Asn70Ser
- ExAC rs774142858
- gnomAD rs774142858
- Missense
- Variant Prioritization Score for Impact Estimate 0.321
- REVEL 0.19
- MetaLR 0.16
- MetaSVM -0.82
- CADD 13.60
- PolyPhen-2 0.02
- SIFT 0.65
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available