L66S (p.Leu66Ser) variant of TLR3 (Toll-like receptor 3)
L66S (p.Leu66Ser) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data and structural context.
L66S (p.Leu66Ser) variant details
- p.Leu66Ser
- gnomAD rs1344959698
- Missense
- Variant Prioritization Score for Impact Estimate 0.674
- REVEL 0.68
- MetaLR 0.73
- MetaSVM 0.63
- CADD 24.50
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available