L63F (p.Leu63Phe) variant of TLR3 (Toll-like receptor 3)
L63F (p.Leu63Phe) in TLR3 (Toll-like receptor 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
L63F (p.Leu63Phe) variant details
- p.Leu63Phe
- NCI-TCGA Cosmic COSV5716
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.287
- REVEL 0.20
- MetaLR 0.33
- MetaSVM -0.51
- CADD 23.10
- PolyPhen-2 0.54
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available