L5F (p.Leu5Phe) variant of TLR3 (Toll-like receptor 3)
L5F (p.Leu5Phe) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
L5F (p.Leu5Phe) variant details
- p.Leu5Phe
- ExAC rs764928979
- gnomAD rs764928979
- Missense
- Variant Prioritization Score for Impact Estimate 0.201
- REVEL 0.13
- MetaLR 0.11
- MetaSVM -0.99
- CADD 10.10
- PolyPhen-2 0.37
- SIFT 0.08
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available