L58F (p.Leu58Phe) variant of TLR3 (Toll-like receptor 3)
L58F (p.Leu58Phe) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data, published literature, and structural context.
L58F (p.Leu58Phe) variant details
- p.Leu58Phe
- gnomAD 4-186076791-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.549
- REVEL 0.52
- MetaLR 0.57
- MetaSVM 0.18
- CADD 24.20
- PolyPhen-2 0.97
- SIFT 0.01
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available